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The Science of MigreLief Supplements for Migraine Sufferers

Under: Migraine & Headache, Migraine Library, MigreLief, MigreLief Original, MigreLief Products

Magnesium, Riboflavin and Puracol® Feverfew – Triple Therapy for Migraine Sufferers

Migraine is a neurological disease with symptoms ranging from severe head pain, visual disturbances, vertigo, nausea, and sensitivity to light, sound or smell. Approximately 40 million Americans suffer migraines which can last from hours to days. For many men, women and children, migraine attacks not only disrupt quality of life, they are also debilitating. Nutritional deficiencies, inflammation and vasospasm can independently and together contribute to migraine occurrence, frequency and intensity.

The dysfunctional brain processes that have been shown to be present in migraine sufferers during migraine attacks include:

• Excessive platelet aggregation resulting in vasospasms due to serotonin release.
• Decrease in the brain cell’s mitochondrial energy reserves.

The ‘Triple Therapy’ combination of Magnesium, Riboflavin and Feverfew have been proven in double blind placebo-controlled studies to be beneficial to migraine sufferers. This combination helps maintain healthy cerebrovascular tone and function while promoting healthy mitochondrial energy reserves.





Studies have shown migraine sufferers with poor cerebrovascular tone have low levels of magnesium. Magnesium is a natural mineral that is necessary for healthy bodily function as it promotes heart health, stabilizes blood pressure, regulates nerve and muscle function and builds bone, DNA and protein. Magnesium is intimately involved in the control of N-methyl-D-aspartate (NMDA) glutamate receptors which play an important role in pain transmission in the nervous system and in the regulation of cerebral blood flow. Magnesium ions plug the NMDA receptors which renders calcium unable to exert its vasodilatory effects.

Magnesium has numerous effects that support cerebrovascular tone and function including the following mechanisms of action:

• Inhibition of platelet aggregation
• Interference with synthesis, release and action of inflammatory mediators
• Direct alterations of cerebrovascular tone
• Inhibition of vasospasm
• Stabilization of cell membranes.

Riboflavin (Vitamin B-2)

Research has shown that a mitochondrial defect may reduce an individual’s threshold to migraine triggers and lead to migraines. A deficiency of mitochondrial energy reserves has been observed in many people exhibiting poor cerebrovascular tone. Riboflavin is a water-soluble vitamin that helps the body convert food to energy. It is a precursor of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN ) which unlike CoQ10 are involved in all three cellular energy production processes; glycolysis, krebs cycle and electron transport. At the proper dose, riboflavin helps maintain healthy mitochondrial energy reserves which is very beneficial to migraine sufferers.


The herb feverfew (Tanacetum Parthenium) has been recorded as a medicinal remedy for millennia. Commonly recommended for its ability to support cerebrovascular tone, feverfew is rich in compounds known as sesquiterpene lactones and glycosides. While much of the feverfew research focuses on parthenolide, a type of sesquiterpene lactone, Akeso feels this is myopic and ignores studies that show feverfew benefits when the parthenolides are removed. While parthenolide may help, the presence of a full spectrum of other feverfew phytochemicals that Akeso has identified is what really makes the difference.

Scientific studies show feverfew inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules. Feverfew also inhibits pro-inflammatory prostaglandin synthesis and the release of arachidonic acid, making it beneficial to migraine sufferers.

MigreLief Triple Therapy with Puracol®

The world-class efficacy of MigreLief’s original patented formula is, for the most part, a result of the research and investment in feverfew chemistry that Akeso Health Sciences pioneered leading to the development of Puracol® feverfew. The unique profile of the phytochemicals present in Puracol® feverfew go beyond industry standards and give MigreLief users a significant advantage in achieving the results they seek.

4 Nutritional Options for Migraine Sufferers

MigreLief 4 Formulas

Recommended by neurologists and headache specialists for twenty-five years, Akeso’s line of MigreLief supplements include four nutritional options: Three daily maintenance formulas for chronic migraine sufferers; MigreLief Original (teens & adults), Children’s MigreLief (age 2-12) and MigreLief+M (for women with menstrual / hormonal migraine) PLUS a fast-acting “as needed” formula, MigreLief-NOW.


Action Step 1
Choose one of MigreLief’s 3 daily formulas: (Original MigreLief (teens and adults), Children’s MigreLief (age 2-12 or under 100 lbs), or Menstrual MigreLief+M) and take twice a day, every day (1 caplet in the a.m. and one caplet in the p.m.).  Stick with it for 3 months for maximum benefits and optimum results.  It will grow in effectiveness over this time period.  1 bottle is a 30-day supply. MigreLief comes with a 90-day satisfaction guarantee when purchased at – So don’t give up too early and miss the opportunity to feel the difference MigreLief can make.

Action Step 2
Take fast-acting MigreLief-NOW “as-needed” for on-the-spot nutritional support and neurological comfort. MigreLief -NOW is a great back-up supplement to take at first warning signs during difficult times.  We recommend keeping MigreLief-NOW on hand during the build-up period when taking a MigreLief daily formula.

Note:  Take MigreLief with food, and it is very beneficial for migraine sufferers to stay well hydrated and get plenty of sleep.

All of Akeso Health Sciences’ condition-specific dietary supplements are formulated by Chief Scientific Officer, Curt Hendrix, M.S., C.C.N., C.N.S. Curt has dedicated his life to researching and developing natural medicines for improving health and longevity and has been a principal scientific investigator for multiple NIH (National Institutes of Health) studies researching the effects of nutritional supplements on Alzheimer’s disease.

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These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.