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The Science of MigreLief Supplements for Migraine Sufferers

December 27th, 2018

Magnesium, Riboflavin and Puracol™ Feverfew – Triple Therapy for Migraine Sufferers

Migraine is a neurological disease with symptoms ranging from severe head pain, visual disturbances, vertigo, nausea, and sensitivity to light, sound or smell. Approximately 37 million Americans suffer migraines which can last from hours to days. For many men, women and children, migraine attacks not only disrupt quality of life, they are debilitating. Nutritional deficiencies, inflammation and vasospasm can independently and together contribute to migraine occurrence, frequency and intensity.

The dysfunctional brain processes that have been shown to be present in migraine sufferers during migraine attacks include:

• Excessive platelet aggregation resulting in vasospasms due to serotonin release.
• Decrease in the brain cell’s mitochondrial energy reserves.

The ‘Triple Therapy’ combination of Magnesium, Riboflavin and Feverfew have been proven in double blind placebo-controlled studies to be beneficial to migraine sufferers. This combination helps maintain healthy cerebrovascular tone and function while promoting healthy mitochondrial energy reserves.

Magnesium
Studies have shown migraine sufferers with poor cerebrovascular tone have low levels of magnesium. Magnesium is a natural mineral that is necessary for healthy bodily function as it promotes heart health, stabilizes blood pressure, regulates nerve and muscle function and builds bone, DNA and protein. Magnesium is intimately involved in the control of N-methyl-D-aspartate (NMDA) glutamate receptors which play an important role in pain transmission in the nervous system and in the regulation of cerebral blood flow. Magnesium ions plug the NMDA receptors which renders calcium unable to exert its vasodilatory effects.

Magnesium has numerous effects that support cerebrovascular tone and function including the following mechanisms of action:

• Inhibition of platelet aggregation
• Interference with synthesis, release and action of inflammatory mediators
• Direct alterations of cerebrovascular tone
• Inhibition of vasospasm
• Stabilization of cell membranes.

Riboflavin (Vitamin B-2)
Research has shown that a mitochondrial defect may reduce an individual’s threshold to migraine triggers and lead to migraines. A deficiency of mitrochondrial energy reserves has been observed in many people exhibiting poor cerebrovascular tone. Riboflavin is a water-soluble vitamin that helps the body convert food to energy. It is a precursor of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN ) which unlike CoQ10 are involved in all three cellular energy production processes; glycolysis, krebs cycle and electron transport. At the proper dose, riboflavin helps maintain healthy mitochondrial energy reserves which is very beneficial to migraine sufferes.

Feverfew
The herb feverfew (Tanacetum Parthenium) has been recorded as a medicinal remedy for millennia. Commonly recommended for its ability to support cerebrovascular tone, feverfew is rich in compounds known as sesquiterpene lactones and glycosides. While much of the feverfew research focuses on parthenolide, a type of sesquiterpene lactone, Akeso feels this is myopic and ignores studies that show feverfew benefits when the parthenolides are removed. While parthenolide may help, the presence of a full spectrum of other feverfew phytochemicals that Akeso has identified is what really makes the difference.

Scientific studies show feverfew inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules. Feverfew also inhibits pro-inflammatory prostaglandin synthesis and the release of arachadonic acid.

MigreLief Triple Therapy with Puracol™
Migrelief for Migraine Relief

The unique MigreLief ‘Triple Therapy’ formulation received 2 U.S. patents with a third patent pending. The world class efficacy of MigreLief is, for the most part, a result of the research and investment in feverfew chemistry that Akeso Health Sciences pioneered leading to the development of Puracol™ feverfew. The unique profile of the phyto chemicals present in Puracol™ feverfew go beyond industry standards and give MigreLief users a significant advantage in achieving the results they seek.

4 Nutritional Options
Migraine Relief

Recommended by neurologists and headache specialists for two decades, Akeso’s line of MigreLief supplements include four nutritional options: Three daily maintenance formulas for chronic migraine sufferers; MigreLief Original, Children’s MigreLief (age 2-12) and MigreLief+M (menstrual migraine) PLUS an “as needed” on-the-spot formula, MigreLief-NOW.

All of Akeso Health Sciences’ condition-specific dietary supplements are formulated by Chief Scientific Officer, Curt Hendrix, M.S., C.C.N., C.N.S. an authority on natural remedies. He has been a principal scientific investigator for multiple National Institutes of Health studies researching the effects of nutritional supplements on Alzheimer’s disease.

For more information visit MigreLief.com or email HealthAdvisor@MigreLief.com

 

References: The Journal of the American Nutraceutical Association. Vol; 6, No. 4, Fall 2003. Magnesium, Feverfew, and Riboflavin: Therapeutic Use in Migraine Prevention.
Andrea Cohen, M.D., Lisa Colodny, Pharm D, Nordia Bryan, PharmD, Samantha Luong, PharmD, Jennifer Rooney, PharmD.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Warning: Anti-Depressants and Migraine Prescription Drugs

July 20th, 2012

FDA Warns on Mixing Antidepressants with Migraine Drugs (First released in 2010)

ROCKVILLE, Md., July 20 — Mixing common migraine drugs with antidepressants can trigger a life-threatening condition called serotonin-syndrome, the FDA has warned.

Serotonin-syndrome is characterized by rapid heart beat, sudden changes in blood pressure, and increased body temperature. Other symptoms include restlessness, hallucinations, loss of coordination, overactive reflexes, nausea, vomiting, and diarrhea.

Options successful at preventing the occurrence of migraines would decrease the risk described above in patients taking anti-depressant and experiencing migraines.  

For warning signs of serotonin syndrome and more info on Anti-depressants and migraine drugs click on the link at the end of this article.  For information on your natural migraine control option recommended by doctors, neurologists and pharmacists, go to  www.MigreLief.com

MigreLief is a dietary supplement for the nutritional support of cerebrovascular function in migraine sufferers age 2 years and above.

RELATED ARTICLE:  ANTI-DEPRESSANTS AND MIGRAINES – A POTENTIALLY DANGEROUS COMBINATION!   Symptoms of Serotonin Syndrome etc…

 

SINUS HEADACHE OR MIGRAINE?

October 30th, 2011

Thousands of people take allergy and sinus medications because they believe the pain they are experiencing are due to sinus headaches. These people often do not get relief because in fact they are having migraines and not sinus headaches.

This article published in Health Central helps to clarify what the source of your headaches may truly be.

Oct 28th 2011

~ Did you know that nearly 90% of what people think are sinus headaches are actually migraines? These are some of the symptoms that make people think they have a sinus headache:

  • * Runny nose or nasal congestion5
  • * Teary eyes
    * Red or puffy eyes
    * Facial pain or pressure

Trigeminal Nerve

All of those can be migraine symptoms. A migraine can inflame the trigeminal nerve. The trigeminal nerve has branches in the face. One runs above the eyes, one runs along the sinuses, and the third runs along the lower jaw. As a result, the pain may be felt near the sinuses, which are air pockets between bones in the lower forehead, cheeks and behind the nose.  Sinus headaches rarely occur unless you have a sinus infection.  ~

If these headaches are occurring many times a month and you have 15 days or more a month that you have headache symptoms, you may be experiencing chronic migraines and are a good candidate for prevention. 

You may be able to eliminate or reduce the number of headache days you have and/or reduce the intensity of your headaches. You may also be able to significantly reduce the amount of medication you take as well.  Visit www.migrelief.com for mor information.

 

Curt Hendrix, M.S., C.C.N., C.N.S.

Can Migraines Affect the Cognitive Performance of Your Child?

May 26th, 2011

 
The cognitive performance of 30 children between the ages of 8-12 years old, with migraines, was compared to the cognitive performance of 30 similarly aged children, without migraines, using the Wechsler Intelligence Scale for Children.

The  study, which was conducted at the department of Neurology and Neurosurgery at the Federal University of Sao Paulo, in Brazil, found that despite the fact that both groups exhibited normal cognitive performance, the children with migraines had much lower scores in the areas of arithmetic, vocabulary, perceptual organization and resistance to distraction and processing speed.

Future studies, aimed to see if preventing migraines in these children would raise their cognitive performance levels in these areas where they were low, would be of significant interest.

 

To learn about gentle, safe and effective options for children suffering with chronic migraines, visit: Children’s Migrelief