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The Science of MigreLief – Nonprescription Dietary Supplements for Adult & Pediatric Migraines


MigreLief Original Formula should be part of your “Preventive” regimen.  It is not an “Abortive.” MigreLief was formulated to help migraineurs maintain normal cerebrovascular (blood vessels that supply the brain) tone and function by addressing the underlying nutritional deficiencies and imbalances that are common to many migraine sufferers. These deficiencies lead to many dysfunctional processes in the brain.

The Science of MigreLief - Migraine Control


MigreLief is a great option and good place to start… a vitamin, a mineral and a plant, all well known for their safety, efficacy and low side-effects to establish normal cerebrovascular function instead of a lifetime on pain killers and drugs.  Magnesium, riboflavin (B-2) and the herb feverfew are listed in the American Academy of Neurology’s Evidence Based Guidelines for Migraine Prevention.  Puracol, Akeso Health Sciences proprietary blend of two  feverfew sources (whole leaf and extract), magnesium (oxcide and citrate) and high dose riboflavin (Vitamin B-2) have independently shown to have significant benefits for chronic migraine sufferers.


Nutritional deficiencies, inflammation, and vasospasm can independently and together contribute to migraine occurrence, frequency and intensity.  The multi-patented combination of ingredients in MigreLief was formulated to address the underlying dysfunctional processes in the brain that often lead to migraines once triggered. MigreLief helps to reestablish and maintain normal cerebrovascular function by addressing the nutritional deficiencies and imbalances often associated with migraines such as:

*Excessive Platelet Aggregation resulting in blood vessel changes.

*Decrease in the brain’s cellular energy reserves.  Cells lose energy production ability when the powerhouses of the cells (the mitochondria) become dysfunctional due to nutritional deficiencies.


Migrelief – Triple Therapy Ingredients: 

Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone.

These include:

1) inhibition of platelet aggregation
2) interference with synthesis, release, and action of inflammatory mediators
3) direct alterations of cerebrovascular tone
4) inhibition of vasospasm
5) stabilization of cell membranes.

Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency, far above what’s found in most multi-vitamins. Several double blind placebo controlled studies have demonstrated that oral magnesium can reduce the frequency and intensity of migraine headaches in both adults and children.

Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain.

MigreLief provides 400 mg of riboflavin. Multiple studies have demonstrated that high dose riboflavin can be beneficial to both adults and children who suffer migraines.

Puracol Feverfew
Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum Parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. .

Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non-extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. For this reason Puracol Feverfew, AKESO HEALTH SCIENCE’S proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide was developed.  Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena is associated with migraines. European studies have shown the benefits of feverfew on long-term cerebrovasular tone in multiple human studies.


The World Health Organization lists migraines 19th among the world’s most debilitating and disabling diseases

Migraine is the most common neurological condition in the developed world: it is more prevalent than asthma, epilepsy and diabetes combined.  In the United States alone, 37 million people .

MigreLief is a wonderful nutritinal option for migraine sufferers and has been recommended my neurologists, headache specialists and other healthcare professionals thoughout the United States and world wide.

Magnesium, riboflavin and the herb feverfew are listed in the American Academy of Neurology’s Evidence Based Guidelines for Migraine Prophylaxis.

Curt Hendrix, M.S., C.C.N., C.N.S. and Chief Scientific Officer of Akeso Health Sciences, formulated and patented MigreLief Triple Therapy with Puracol was well received by physicians at the recent Pri-Med convention and explained the science behind the success of MigreLief to a very interested audience.

Most MigreLief fans already know that MigreLief was formulated to addresses the underlying nutritional deficiencies and imbalances that are common to many migraine sufferers. But for those newcomers lucky enough to have stumbled upon MigreLief for the first time…it is not an “abortive” to treat the pain while it is occurring. It is nutritional support and daily maintenance.

MigreLief-NOW is Akeso’s fast-acting “as-needed” formula that can be take at the first sign of discomfort.  It can be used by itself as needed or combined with MigreLief Original, Children’s MigreLief or MigreLief+M (mestrual migraines).  For additinal nutritional support, 2 MigreLief-NOW capsules can be added to the morning dose of any MigreLief daily maintenance product.



MigreLief should be your first choice for migraine therapy… not the last!
Too often sufferers opt for the more invasive, complex often side-effect prone prescription drugs, botox or other approaches to their problem. MigreLief is a more natural option (vitamin, mineral and herb), it’s inexpensive and it addresses the underlying problem (it does not just mask the symptoms or temporarily ease the pain). To get started, select one of the daily formulas (MigreLief, Children’s MigreLief, or MigreLief+M for menstrual migraines), and take as recommended every day for a full 90 days to experience the benefits and evaluate how it works for you.  MigreLief-NOW is a fast-acting as-needed formula which is ideal to have on hand for those tough days when you need extra help.


100% MONEY BACK GUARANTEE – Try MigreLief Risk Free   

We’re so confident that MigreLief will make a difference, if anyone is dissatisfied for any reason, we offer a 100% money back guarantee of the product purchase price for new customers trying MigreLief for 90 days (each bottle is a one month supply).  Although many consumer/patients experience beneficial results in as little as 3 weeks, it is recommended that it be taken for the full 3 months to build blood levels for maximum effectiveness.

MigreLief can be safely combined with prescription migraines or OTC medications.  It has been known to lessen the side-effects of certain prescription drugs for many users. You may discover while taking MigreLief that you’ve effectively weaned yourself off of other migraine meds as you reach for them less and less.


Track your MigreLief progress with our Migraine Diary and Trigger Tracker. – Product Information

MigreLief Store Finder



The Man Behind “MIGRELIEF” – Making a Difference in the Lives of Migraine Sufferers Worldwide for over 20 years

Subscribe to receive the Curt Hendrix Longevity & Disease Prevention BulletinCurt Hendrix, M.S, C.C.N, C.N.S, is the Chief Scientific Officer for Akeso Health Sciences, the manufacturer of the highly successful, comprehensive nutritional migraine supplement “MigreLief® Triple Therapy with Puracol™’.  Multi-patented MigreLief was made available to the public in 1997, and is a 100% drug-free dietary supplement formulated to help maintain normal cerebrovascular tone and function in chronic migraine sufferers.  Curt is dedicated to the research and development of condition-specific natural medicines and innovative leading-edge solutions for migraine sufferers worldwide.

Curt has been named as the Principal Scientific Investigator in multiple National Institutes of Health (NIH) governmental grants studying the benefits of natural medicines on Alzheimer’s disease.

A Unique Perspective
With a focus on nutritional applications of herbal and natural medicine (based on scientific application) Curt’s unique combination of education, training, and experience in chemistry, medicine, nutrition, the supplement industry, NIH sponsored research, and pharmaceutical drug development, generates a perspective leading to an intimate understanding of the workings of the human body.  After spending two years in a physical chemistry Ph.D. program at the City University of New York, Curt obtained a Master’s Degree in Human Nutrition from the University of Bridgeport. He is board-certified both in clinical nutrition (CCN) and as a nutrition specialist (CNS) from the American Academy of Nutrition.

Curt has spent the last several decades researching and archiving the potential benefits, effects and mechanisms of literally thousands of naturally occurring compounds (plants, amino acids, vitamins/minerals and their metabolites and other nutrients and supplements).  His efforts in developing “natural-based” medicines led to his creating disease-specific monographs in areas such as Migraine, Osteoporosis, Osteoarthritis, Benign Prostatic Hyperplasia, Depression and more, approved for Continuing Education credits for physician license renewal.

His extensive research, knowledge and expertise have also led to the formulation and manufacturing of various condition-specific nutritional supplements.  Some of these supplements and drugs are currently available to the public, others are pending release. He holds many U.S. patents with additional patents pending.

Researching and developing safer natural medicines and leading-edge solutions to combat disease keep Curt busy but he still finds time to travel throughout the United States, sharing the science behind the success of  MigreLief’s line of nutritional supplements for migraine sufferers.

CREATING MIGRELIEF – a personal note:

I understand the impact that migraines have on the life of a sufferer, their friends and loved ones.  For the past 27 years, I lived with the pain, worry and fear that migraine attacks bring on. When my wife was an adolescent, she hit her head on the windshield of the car during an automobile accident. From that day on, chronic, painful migraines were a consistent part of her life.  We spent years hoping that each migraine would not progress and lead to another trip to the emergency room for a shot of morphine and other very powerful drugs we desperately wanted to avoid.

Even the prescription drugs that my wife’s headache specialists recommended had significant side effects. They would sometimes help the migraine pain to diminish or resolve only to find that her migraine would come back in a day or two.  The more medication my wife used for migraines, the more rebound headaches she would have, creating a vicious cycle of prescription drug use.  I found that unacceptable, so as a chemist and researcher I learned everything I could about migraines hoping to help my wife avoid a lifetime of merely treating the pain with side-effect prone drugs.

I formulated MigreLief® Triple Therapy with Puracol™ as a result of my research and received two United States patents for a combination of three naturally occurring ingredients that have since helped hundreds of thousands of migraine sufferers for over two decades.

I am thrilled to know that MigreLief was makes a difference in the lives of countless sufferers and I never get tired of reading the heart-warming success stories from long-time sufferers or receiving feedback from health care professionals.  It inspires all of us at Akeso Health Sciences, a family-owned company, to work diligently to inform the world of this great nutritional option.

Curt Hendrix, M.S., C.C.N., C.N.S.