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The Science of MigreLief – Nutritional Supplements for Migraine Sufferers

Under: Migraine & Headache, MigreLief, MigreLief Original, MigreLief Products


MigreLief Original Formula should be part of your “Preventive” regimen.  It is not an “Abortive.” MigreLief was formulated to help migraineurs maintain normal cerebrovascular (blood vessels that supply the brain) tone and function by addressing the underlying nutritional deficiencies and imbalances that are common to many migraine sufferers. These deficiencies lead to many dysfunctional processes in the brain.

The Science of MigreLief - Migraine Control


MigreLief is a great option and a good place to start… a vitamin, a mineral, and a plant, all well known for their safety, efficacy, and low side-effects to establish normal cerebrovascular function.  Magnesium, riboflavin (B-2), and the herb feverfew are listed in the American Academy of Neurology’s Evidence-Based Guidelines for Migraine Prevention.  Puracol, Akeso Health Sciences proprietary blend of two feverfew sources (whole leaf and special feverfew extract), magnesium (oxide and citrate), and high dose riboflavin (Vitamin B-2) have independently been shown to have significant benefits for chronic migraine sufferers.


Nutritional deficiencies, inflammation, and vasospasm can independently and together contribute to migraine occurrence, frequency, and intensity.  The multi-patented combination of ingredients in MigreLief was formulated to address the underlying dysfunctional processes in the brain that often lead to migraines once triggered. MigreLief helps to maintain normal cerebrovascular function by addressing the nutritional deficiencies and imbalances often associated with migraines such as:

*Excessive Platelet Aggregation resulting in blood vessel changes.

*Decrease in the brain’s cellular energy reserves.  Cells lose energy production ability when the powerhouses of the cells (the mitochondria) become dysfunctional due to nutritional deficiencies.


Migrelief – Triple Therapy Ingredients:

Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone.

These include:

1) inhibition of platelet aggregation
2) interference with synthesis, release, and action of inflammatory mediators
3) direct alterations of cerebrovascular tone
4) inhibition of vasospasm
5) stabilization of cell membranes.

Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency, far above what’s found in most multi-vitamins. Several double-blind placebo-controlled studies have demonstrated that oral magnesium can reduce the frequency and intensity of migraine headaches in both adults and children.

Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain.

MigreLief provides 400 mg of riboflavin. Multiple studies have demonstrated that high-dose riboflavin can be beneficial to both adults and children who suffer migraines.

Puracol Feverfew
Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum Parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness.

Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non-extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. For this reason, Puracol Feverfew, AKESO HEALTH SCIENCE’S proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide was developed.  Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachidonic acid. Each of these phenomena is associated with migraines. European studies have shown the benefits of feverfew on long-term cerebrovascular tone in multiple human studies.

The World Health Organization lists migraines 19th among the world’s most debilitating and disabling diseases

Migraine is the most common neurological condition in the developed world: it is more prevalent than asthma, epilepsy, and diabetes combined.  In the United States alone, 37 million people.

MigreLief is a wonderful nutritional option for migraine sufferers and has been recommended by neurologists, headache specialists, and other healthcare professionals throughout the United States and worldwide.

Magnesium, riboflavin, and the herb feverfew are listed in the American Academy of Neurology’s Evidence-Based Guidelines for Migraine Prophylaxis.

Migrelief Scientist

Curt Hendrix, M.S., C.C.N., C.N.S. and Chief Scientific Officer of Akeso Health Sciences, formulated and patented MigreLief Triple Therapy with Puracol was well received by physicians at the recent Pri-Med convention and explained the science behind the success of MigreLief to a very interested audience.

Most MigreLief fans already know that MigreLief was formulated to address the underlying nutritional deficiencies and imbalances that are common to many migraine sufferers. But for those newcomers lucky enough to have stumbled upon MigreLief for the first time…it is not an “abortive” to treat the pain while it is occurring. It is nutritional support and daily maintenance.

MigreLief-NOW is Akeso’s fast-acting “as-needed” formula that can be taken at the first sign of discomfort.  It can be used by itself as needed or combined with MigreLief Original, Children’s MigreLief, or MigreLief+M (menstrual migraines).  For additional nutritional support, 2 MigreLief-NOW capsules can be added to the morning dose of any MigreLief daily maintenance product.


MigreLief should be your first choice for migraine therapy… not the last!
Too often sufferers opt for the more invasive, complex often side-effect-prone approaches to their problem. MigreLief is an inexpensive, drug-free nutritional option (vitamin, mineral, and herb) that addresses the underlying deficiencies and imbalances common to many migraine sufferers.

MigreLief 4 Formulas

MIGRELIEF REGIMEN:  To get started, select one of the daily formulas (MigreLief, Children’s MigreLief, or MigreLief+M for menstrual migraines), and take as recommended every day for a 90 days to experience the full benefits and evaluate how it works for you.  We suggest keeping fast-acting MigreLief-NOW on hand to be taken as-needed during the 90 day build-up period or any time you fell you need extra support.


100% MONEY BACK GUARANTEE – Try MigreLief Risk-Free  

We’re so confident that MigreLief will make a difference, if anyone is dissatisfied for any reason, we offer a 100% money-back guarantee of the product purchase price for new customers trying MigreLief for 90 days (each bottle is a one month supply).  Although many consumers/patients experience beneficial results in as little as 3 weeks, it is recommended that it be taken for the full 3 months to build blood levels for maximum effectiveness.

Note:  MigreLief does not interfere with prescription migraine or OTC medications.


Track your MigreLief progress with our Migraine Diary and Trigger Tracker. – Product Information

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