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FDA Warning: Anti-Depressants and Migraine Prescription Drugs

FDA Warns on Mixing Antidepressants with Migraine Drugs (First released in 2010)

ROCKVILLE, Md., July 20 — Mixing common migraine drugs with antidepressants can trigger a life-threatening condition called serotonin-syndrome, the FDA has warned.

Serotonin-syndrome is characterized by rapid heart beat, sudden changes in blood pressure, and increased body temperature. Other symptoms include restlessness, hallucinations, loss of coordination, overactive reflexes, nausea, vomiting, and diarrhea.

Options successful at preventing the occurrence of migraines would decrease the risk described above in patients taking anti-depressant and experiencing migraines.  

For warning signs of serotonin syndrome and more info on Anti-depressants and migraine drugs click on the link at the end of this article.  For information on your natural migraine control option recommended by doctors, neurologists and pharmacists, go to

MigreLief is a dietary supplement for the nutritional support of cerebrovascular function in migraine sufferers age 2 years and above.



Still Suffering Migraines? This Story Will Give You Hope!

Every day more and more migraine sufferers are discovering MigreLief as their natural preventive alternative to a life time of suffering migraine symptoms and pain.  Our efforts to reach sufferers and health care professionals world wide are fueled by heartfelt letters of gratitude and appreciation from our fans.  We’d like to thank you all for your wonderful feedback and support.  For those of you who have not tried MigreLief and are still running the gambit of prescription drugs and other treatments unsuccessfully…the letter below from a new MigreLief fan will give you hope.

~ Curt Hendrix and The MigreLief Team.

Tanya’s Story

I took a huge chance when I bought MigreLief.  Suffering from migraines (Daily Chronic Headache) for over 11 years, I have gone through three neurologists, attended one of the best headache clinics in the country, taken so many different types of medication, I can\’t remember half of them, and most recently tried Botox twice (it worsened my migraines), I was, of course leery…very leery.

However, on the other side, I thought, with no side effects, what could it hurt to give it a try. I will freely admit, I wasn\’t hopeful.

I have been taking MigreLief+M for about 2 months, and if I could, I would shout from the rooftops how incredible this product is! I would be your spokesperson in a heartbeat! It is nothing short of a miracle, and I am so ecstatic about how I am feeling.

I have been keeping track of my migraines for months, and I am watching them decrease again and again. Particularly, for over 5 weeks I have not once had 2 migraines in a row. This, for me, is absolutely incredible.

There are times when I suffer 7-10 days in a row, using all of my relief medicine, but with the thought in the back of my mind on how it may be effecting my body, and knowing that I am probably causing rebound headaches.

Your product is simply amazing, and I know that there are probably thousands of people who come to your site and think it won\’t work for them, or think it\’s just some silly scam product. Honestly, I did the same thing for over a year before I took the plunge.

I thank God above that I finally decided to give MigreLief a chance, and I pray that you do not stop offering this product.  I only wish that more doctors would tell their patients about it instead of trying to give us chemical-filled medication that takes away a couple of headaches but in return gives us horrible side effects.

There is no way for me to thank you enough. You have no idea how your product is changing my life – yes, my life. I can\’t remember the last time that I didn\’t think \”will I have a migraine today\”? I have actually stopped worrying about that. I have had 4 migraines in the past 4 weeks. This compares to an average of 15 I typically get in a month (up to 21). Thank you thank you thank you!!!! Bless you!!

Tanya Bowser

Tim’s Story

MigreLief Testimonials – Physician & Patient Consumers

MigreLief Information

Antidepressants & Migraines – A Potentially Dangerous Drug Combination



Antidepressants combined with Migraine Drugs possibly dangerousTaking antidepressants, like Pristiq, along with certain migraine medications can lead to dangerous and even life-threatening side-effects.

Many people who suffer from depression also suffer from migraine headaches. Unfortunately, the mechanism of action of many antidepressants is to increase serotonin (a feel good neurotransmitter) levels in the brain. Triptan drugs like Imitrex, which are used to reduce or end the pain of a migraine attack also work by stimulating serotonin receptors.

This combination of antidepressants and triptan migraine drugs, can lead to too much serotonin in the brain. This is not a good thing and can result in a potentially life-threatening condition known as “serotonin syndrome.”

Though not approved for migraine prevention by the FDA, some physicians recommend antidepressants like Pristiq, for this purpose. There is very little data supporting this recommendation and not insignificant risk if they are also used with the triptan drugs like Imitrex or Zomig.

In some people, just the use of triptans alone can result in unhealthy levels of serotonin, leading to serotonin syndrome. This risk increases substantially if these people are also taking an antidepressant like Pristiq or any other of several antidepressants known either as SSRI (selective serotonin reuptake inhibitors) or SNRI (serotonin-noradrenaline reuptake inhibitors).

The symptoms of “serotonin syndrome” are:

Rapid heart rate and high blood pressure
Agitation or restlessness
Dilated pupils
Loss of muscle control or twitching muscles
Heavy sweating
Goose bumps

In severe cases of serotonin syndrome life-threatening symptoms can occur:

High Fever
Irregular heart beat

If you and your physician decide to use this combination of drugs, you must be monitored very closely for any of these signs and symptoms of serotonin syndrome.

If your migraines are bad enough, your physician may decide to stop the antidepressant so that you can use the triptan drugs with less risk (though as mentioned above, they alone, in some users can cause serotonin syndrome).

A win-win solution for many migraine sufferers who are also suffering with depression is to switch to the all natural migraine prevention supplement, MigreLief.

Prevention is clearly desirable rather than to constantly just treating the pain of migraines and there is no additional risk of serotonin syndrome when using MigreLief.

Knowledge is power.

Be well,

Curt Hendrix B.S. M.S. C.C.N. C.N.S.




Migrelief FinalMIGRELIEF

The only multi-patented, physician recommended nutritional supplement for either men, women or children over 12  years of age, who suffer from chronic migraine.

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