[Study] High Dose Riboflavin Can Reduce Frequency and Intensity of Migraines

May 12th, 2012

Some people think of migraine headaches as being an adult health problem. Children of all ages suffer from migraine pain which can disrupt and impair their quality of life as well. According to the American Academy of Family Physicians, about 5% of elementary school-age children may experience migraine headaches and the physical and emotional stress they cause. This statistic jumps to 20 percent by the time a child reaches high school.

Before age 10, an equal number of boys and girls get migraines but after age 12 during and after puberty, migraines affect girls three times more than boys. Migraine symptoms interrupt the normal activities of 65-80% of these young migraineurs.

In addition to possible emotional changes such as sadness and anxiety affecting the quality of a child’s life, it is well known that many frequently used prescription migraine medications have adverse side-effects in children including dizziness, sleep disturbance and even marked fatigue making the prevention of future migraines the main focus of neurologists, doctors and parents alike.

One of the 3 ingredients in MigreLief, all of which are listed in the American Academy of Neurology Guidelines for Migraine Prevention, is Riboflavin.

Riboflavin, also known as vitamin B2, has a variety of functions, from aiding in the manufacture of red blood cells to assisting in the extraction of energy from carbohydrates, protein, and fat.  Riboflavin has been known to increase cellular energy production  via tiny “energy factories” in the brain cells called mitochondria.

Riboflavin is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some people exhibiting poor cerebrovascular tone.

This defect may be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin, which is significantly higher than most multi-vitamins or B-complex products.

Multiple studies have demonstrated that high dose riboflavin can reduce the frequency and intensity of migraines in both adults and children.

Of the 3  ingredients in MigreLief, it is the high dose Riboflavin that can take up to 90 days to build blood levels sufficient to decrease migraine risk making it  is a very important part of MigreLief’s Triple Therapy for effective migraine prevention.

Below is a study published a couple years ago, that we wanted to re-post  as many of you may not have seen it.

CHILDREN & MIGRAINES – PROMISING RESULTS SHOWN IN RIBOFLAVIN PREVENTION STUDY

Riboflavin Prophylaxis in Pediatric and Adolescent Migraine

Many neurologists are on a quest to find solutions for migraine pain in children as well as adults. A recent study published in The Journal of Headache and Pain show the effectiveness of riboflavin (at the same dose found in MigreLief) as a well-tolerated and low cost preventative treatment in children and adolescents suffering from migraine.

The study was published in August 2009 by M. Condo, A. Posar, A. Arbizzsani, and A Parmeggiani of the Child Neurology and Psychiatry Unit, Department of Neurological Sciences, University of Bologna in Italy. Previous studies have shown that riboflavin is easily tolerable and very effective for preventing migraines in adults however there is not a great deal of data pertaining to children.

This recent study reported on the experience and effects of using riboflavin for migraine prophylaxis in 41 pediatric and adolescent patients, who received 200 or 400 mg/day single oral dose of riboflavin for 3, 4 or 6 months. Attack frequency and intensity decreased during treatment and these results were confirmed during the follow-up.

During the follow-up, 68.4% of cases had a 50% or greater reduction in frequency of attacks and 21% in intensity. Two patients had vomiting and increased appetite, respectively, most likely for causes unrelated to the use of riboflavin. **

Overall, the study concluded that riboflavin seems to be an effective, low cost and well tolerated treatment for the prevention of migraines in children and adolescents.

**Milan, Springer – The Journal of Headache and Pain –
1129-2377 (Online) Volume 10, Number 5, October 2009

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