MigreLief Calm & Clever | MIGRELIEF

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Serving size 2 caplets
Ascorbic Acid (Vitamin C)…………………….250 mg
Pyridoxal-5-Phosphate (Vitamin B-6)……….25 mg
Pantothenic Acid………………………………..25 mg
Bacopa Monnieri……………………………….320 mg
Huperzine A……………………………………200 mcg
Ashwagandha Extract…………………………600 mg
Vinpocetine…………………………………….15 mg
Click here for ingredient descriptions


Why You Need “Calm & Clever”

Students, busy Moms, business people, the elderly and anyone experiencing stress, anxiety and memory issues will benefit from Calm & Clever.

The ingredients in Calm & Clever are shown to reduce the negative effects of stress on your brain, tissues and organs.

Calm & Clever will help you feel calm, centered, and in control, while simultaneously helping you to think clearly and enhance your memory and recall of words, names and facts.

Support your long-term health and longevity – DEFEAT STRESS!

Stress kills – fight back and win with “Calm & Clever”

Stress and anxiety (continued stress even when the initial cause of stress is gone) contribute to increased risk of heart disease, heart attack, depression, excessive belly fat, sexual dysfunction, insomnia, decreased immune function, brain shrinkage, memory issues, cognitive decline and dementia and decrease life expectancy. Acute stress is also the leading cause of sudden death in healthy people.

Stress and Anxiety

EVERYONE, regardless of their age, gender, strength, wealth, health, emotional and psychological make-up, is subject to stress. But the question is… What is stress – and how is it different from anxiety?

Stress comes about due to a physical event you’re currently going through, you anticipate going through, or a newly learned fact or situation that causes you concern. In most if not all cases of stress, you can identify “what is causing you to feel the stress.” Examples can be as simple as the “stress” you feel when trying to lift a heavy weight (physical stress) to the “stress” you feel when starting a new job or learning that a loved one is ill.

On the other hand, if your life, or your response to it, is consistently full of different kinds of stresses for long periods of time, you may be become generally “anxious, fearful or nervous” as a learned behavior even when no obvious “stressor” is present or can be identified.

Prolonged stress or anxiety is associated with poorer health outcomes and increased risk of disease, and diminishes greatly your day to day enjoyment and quality of life. One could make the argument that the opposite of “anxiety” is “calm.” By definition, calm means “not excited, nervous, fearful or agitated – composed.”

The clinically tested “calming” ingredients in Calm & Clever are meant to offset the physical symptoms and emotional and psychological feelings of fear, nervousness and agitation that can be caused by stress or anxiety, and create a peaceful feeling of “CALM” while remaining alert and energetic.

Quicker brain response – better memory, fact and word recall

We aren’t surprised when someone in their 50’s or above complains about declining memory and/or fact or word recall, but the fact is that memory and cognitive function starts to decline as early as the late 20’s or early 30’s. It’s not surprising that stress and anxiety can contribute to poorer cognitive function and students and soldiers have both been shown in clinical trials to perform much less effectively when subject to both physical and psychological stress.

So in addition to the clinically proven stress/anxiety reducing ingredients in “Calm & Clever, Akeso Health Sciences has added proven ingredients that have been shown to enhance cognitive function, memory and the ability to perform challenging tasks when subjected to stress.

Maintaining healthy and youthful brain volume as you age

In this age where sophisticated imaging machines can look at the health of our brains, we’ve learned that several parts of the brain can shrink with aging. This shrinking (atrophy) is associated with poorer brain/cognitive function and may even lead to Alzheimer’s disease.

Akeso Health Sciences has included additional ingredients in “Calm & Clever” that have been shown to help maintain already health and normal levels of brain volume in areas crucial to long-term brain health, cognitive function and memory. Click here to learn more about Calm & Clever’s ingredients.

Calm & Clever is a must for people who want to combat the effects of stress and anxiety on health, memory and over-all brain health and cognitive function.

Each ingredient in Calm & Clever’s “anti-stress/memory cocktail,” both in form and dose, was selected by scientist Curt Hendrix because the human studies published in peer-reviewed medical and research journals spelled out the road map of exactly what you need to do to fight back and “neutralize” stress and anxiety and their negative effects on health, memory and brain function.

The memory of someone who is experiencing chronic stress and anxiety is often compromised. Stress can impact levels of neurotransmitters, enzymes and even some hormones that are intricately involved in memory/recall of words, names, facts and numbers.

“Calm & Clever” is a formulation that delivers what it promises based upon quality, verifiable science.

Curt Hendrix M.S. C.C.N. C.N.S. has been a principal investigator in several NIH studies involving brain function. He formulated “Calm & Clever” using ingredients and doses of those ingredients shown in human randomized, placebo controlled studies, to either reduce stress and/or increase memory and cognitive function.


Calm & Clever Ingredients


Ascorbic Acid (Vitamin C)

Well known for its immune protecting abilities, recent studies link high vitamin C intake with improved mental function and reduced memory loss. A deficiency of vitamin C reduces production of neurotransmitters associated with anxiety.

A recent 2015 study demonstrated that vitamin C could even reduce stress/anxiety in students. Using a well known anxiety scale called the Beck Anxiety Inventory, high school students demonstrated not only reduced anxiety levels but reduced heart rates as well. The researchers suggested that these results indicate that vitamin-C plays an important role for anxiety.

Pyridoxal-5-phosphate (the metabolically active form of vitamin B-6) also known as PLP

Symptoms of B-6 deficiency include:

Pantothenic Acid (Vitamin B5)

Vitamin B-5 produces numerous enzymes and helps maintain precise communication between the central nervous system and the brain. In addition to playing a role in the breakdown of fats and carbohydrates for energy, vitamin B5 is critical to the manufacture of sex and stress-related hormones produced in the adrenal glands. Pantothenic Acid helps to manage stress and psychological strain. A low level of B5 can lead to difficulty coping with stress, inability to relax and problems sleeping.

Bacopa Monnieri (Brahmi)

Brahmi is a well-known herb in India and is frequently used in Ayurvedic herbal preparations to improve memory and intelligence. Clinical studies suggest that bacopa may improve learning rate, ability to process data/information, retention of learned facts and memory. Over 4 weeks bacopa was shown to reduce nervousness and irritability in humans diagnosed with anxiety. Bacopa helps the elderly as well. In a patient population whose average age was 62, bacopa was shown to improve working memory/recall, and improve attention as well as cognitive processing.


Huperzine-A is a neuro-nutrient/compound extracted from the herbs of the Huperziceae family, a Chinese club moss. It is known as an acetylcholinesterase inhibitor, which means that it stops an enzyme from breaking down acetylcholine which results in increases in acetylcholine. Acetylcholine is known as the learning neurotransmitter. Taking huperzine-A orally seems to nutritionally support normal memory, cognitive function, and behavioral function in healthy patients as well as patients with Alzheimer’s, multi-infarct, mild cognitive impairment and senile dementia, making it an important ingredient for the elderly as well.

Ashwagandha (Withania Somnifera)

KSM-66 is a Full spectrum ashwagandha extract derived only from the most valuable parts of the plants, the roots! (None of the plant leaves are ever used.)

Ashwagandha is the most popular medicinal plant used by Ayurvedic practitioners. Indian physicians who practice Ayurveda believed that ashwangandha has the following benefits:

Now, scientific studies in humans, published in respected, peer-reviewed medical/scientific journals support many of the benefits that Ayurvedic practitioners have known about for centuries.

Of interest is that in an in-vitro study of the effects of KSM-66 ashwagandha extract on telomerase activity on the human cell line HELA was measured. Telomerase is the enzyme that protects the telomeres from shortening (the caps at the end of our chromosome which shorten every time a cell replicates and eventually get to the point where the cell has grown too old to replicate properly or at all. In this experiment KSM-66 extract enhanced telemerase activity by approximately 200% which theoretically could significantly enhance the healthy life span of the cell (an anti-aging effect). It is important to caution that both pre-clinical animal studies and in-vitro studies like the one here, are not a guarantee that the same results will or won’t occur in humans. Only well designed human trials can determine that.


Vinpocetine is an herb derived from the seeds of the periwinkle plant. It has been used in traditional Chinese and Indian medicine for centuries and in European clinical practice for over 20 years. Vinpocetine is known for being “neuro-protective” and improves cerebral metabolism.

Clinical studies suggest that vinpocetine may enhance memory even in normal patients. Some evidence indicates that vinpocetine may help the brain use glucose and oxygen more efficiently. Like the heart, optimum blood flow through the vessel of the brain is necessary for healthy cognitive and over-all brain function. Patients with compromised brain vessel function scored significantly higher on mental exams after taking vinpocetine for 3 months.


Click here for further ingredient information and scientific references (PDF)


Calm & Clever Label details:

Calm & Clever Supplement Facts Ingredients Label

Calm & Clever Product Information

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.