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MigreLief (formerly Migre Health and MigreLieve) is a patented combination (patents 6,068,999 and 6,500,450) of 3 natural ingredients, which multiple, double-blind, placebo controlled clinical studies published in top medical journals have shown can affect migraine frequency and intensity*. It contains:
In addition to high dose riboflavin, a specific combination of two forms of magnesium which maximize absorption and efficacy are used in MigreLief. Puracol represents proprietary feverfew science specific to MigreLief as well. While extracts of feverfew can maximize certain phytochemicals found in the whole plant, like parthenolides, the extraction process can also remove other naturally occurring phytochemicals that may be required for maximum efficacy. The puracol technology corrects this problem by simultaneously maximizing parthenolide levels while maintaining the full spectrum of all the other naturally occurring compounds found the whole plant. Research studies show that almost half of all migraine sufferers have low blood levels of Magnesium—which is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines). Migraine sufferers also suffer mitochondrial energy deficiencies, which Riboflavin (Vitamin B2) can improve when given in high dosages. And the plant material Feverfew has been shown to reduce platelet aggregation, which can lead to vasoconstriction. So all 3 ingredients have been recommended for years by many doctors and top headache specialists based on the clinical studies behind them. MigreLief combines all 3 of these ingredients into one formula -- at the dosages the clinical studies show are beneficial. So you take 1 product not 3 products. And you take 2 tablets/day -- versus 4 - 10 tablets/day if taken separately. Plus, MigreLief’s Puracol Feverfew contains high levels of parthenolides and other active components – which other feverfew products cannot guarantee. MigreLief can safely be used with your migraine prescription medications or by itself. See links to the top right for more product information.
MagnesiumMagnesium is a nutritional supplement with numerous effects that support cerebrovascular tone. These include: 1) inhibition of platelet aggregation;2) interference with synthesis, release, and action of inflammatory mediators;3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency -- far above what's found in most multi-vitamins. RiboflavinRiboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide(FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin -- significantly higher than most multi-vitamins or B-complex products. FeverfewCommonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus Puracol Feverfew, AKESO HEALTH SCIENCE'S proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide was developed. Puracol Feverfew, is just one of the reasons for the superior efficacy of MigreLief which delivers optimal dosages of parthenolide. Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena are associated with migraines.* European studies have shown the benefits of feverfew on long-term cerebrovasular tone.
Ingredients
Recommended UsageTake 1 tablet twice daily. MigreLief is designed to provide benefits within the 90 day build up period. Continue daily use if you notice benefits. MigreLief can be used with migraine prescription medicines or by itself. Contraindications, Adverse Reactions or Drug InteractionsSide effects due to any of the ingredients in MigreLief are rare. Mild gastrointestinal upset and loose stools may occur in some persons using magnesium. People using a calcium and magnesium combination supplement may need to change to a calcium only supplement if gastrointestinal upset occurs. A bright yellow colored urine is due to Vitamin B2, and is both normal and safe. This product is not recommended for use during pregnancy or lactation and should not be used in children under the age of two years. Persons taking potassium-sparing diuretics or with renal failure should not use this product. |
Magnesium
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