MigreLief+M

At last - an effective option for menstrual migraines!


Magnesium – Research studies show that almost half of all migraine sufferers have low blood levels of magnesium – which is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines).

Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone.  These include: 1) inhibition of platelet aggregation; 2) interference with synthesis, release, and action of inflammatory mediators; 3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium.(11-16) Recommended daily dosages of magnesium typically range from 400 to 600 mg to compensate for this deficiency — far above what’s found in most multi-vitamins.

Riboflavin (Vitamin B-2) – Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin — significantly higher than most multi-vitamins or B-complex products.
Riboflavin at the dose contained in MigreLief+M has been shown to significantly reduce the frequency and intensity of migraines both in adults and children. (17-20)

Feverfew (Tanacetum parthenium) – Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness for migraines.(1-10) Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus, Puracol Feverfew (AKESO HEALTH SCIENCE’S proprietary non extracted plant source for feverfew) with high levels of naturally occurring parthenolide was developed. Puracol Feverfew, is just one of the reasons for the superior efficacy of MigreLief which delivers optimal dosages of parthenolide.

Chasteberry Standardized Extract
The specific dose and extract of Chasteberry used in MigreLief+M have been shown in numerous studies to establish balance of female hormones as well as testosterone, that can fluctuate greatly around the time of menstruation.

Reestablishing this hormonal balance will either eliminate or significantly reduce many of the symptoms described in the product summary.

The ability of Chasteberry extract to truly “balance hormones” is documented and very impressive.

For example, women who have their periods too frequently (polymennorhia), every 20 days for example, Chasteberry extract can lengthen the time between periods to a more acceptable 25-28 days.

On the other hand, women who have their periods infrequently (oligomennorhia), say every 40-60 days, Chasteberry extract can bring them back to a regular 25-28 day cycle.

Additionally, for women who have very painful periods, or who bleed too heavily during menstruation, this impressive extract can reduce both the pain and excessive bleeding.

As you will later read, Chasteberry extract is extremely effective at alleviating both symptoms of PMS and PCOS.

Finally, for women starting to suffer from menopausal symptoms (also a hormonal imbalance) Chasteberry extract has been shown to be effective as well.

A double-blinded, German study of 178 women given Chasteberry extract examined its effects on PMS symptoms. The researchers found significant improvement of irritability, mood alteration, anger, headache, breast pain and bloating in the patients taking the active Chasteberry versus placebo. The researchers stated that Chasteberry is an effective and well tolerated treatment for the relief of PMS symptoms. (21)

In another study of 117 women with both menstrual cycle issue and/or PMS, who were suffering with acne, administration of Chasteberry extract significantly improved acne after 8 weeks, and over 70% of patients were acne free after 3 months. A second study done many years later, confirmed these results.(22,23)

A study of 126 women who were suffering with menstrual disorders (where either cycles were too short, too long or whose bleeding was excessive), found that treatment with Chasteberry extract administered over 3-4 months, corrected or significantly improved these issues in over 90% of the women. (24)

Women who suffer from PCOS can experience infertility, painful periods, no periods, hairloss and acne. These women often have excessive levels of testosterone as well. Chasteberry extract has been shown to lower testosterone levels, restore or improve hair loss, and resolve acne issues in many of these women.(25)

Who shouldn’t use Chasteberry extract?
It is theoretically possible, that the estrogen levels of women on birth control pills may escalate with the use of Chasteberry extract (Vitex) and render the birth control pills less effective. This has not been shown to happen in any published studies, but is “theoretically” possible.

Women who are on birth control pills should discuss the use of chasteberry with their physician. As previously mentioned, birth control pills can either worsen or improve migraines in certain women. 

Because Chasteberry extract helps with migraines by normalizing estrogen and progesterone production, it should not be used by women who have breast cancer or other estrogen related diseases or conditions. 

It is thought that Chasteberry extract can enhance dopamine levels which can help with increased libido, and this is a favorable effect. But, for patients taking dopamine enhancing drugs like levodopa for Parkinsons, Chasteberry extract may theoretically increase the effect of these drugs and should be discussed with your physician prior to use.

D-Biotin
Fluctuations in blood sugar are strongly related to the occurrence of migraines, the symptoms of PMS and PCOS.
Though biotin supplementation is recommended by many healthcare practitioners and nutritionists for healthy nails and hair, the amount of biotin that is required to stabilize blood sugar levels is 50-100 times higher and not found in off-the-shelf supplements or multi-vitamins.

Being water a water soluble B-vitamin not only is biotin safe at these levels but it may be heart healthy as well because it lowers triglycerides which can contribute to heart disease.

It is at this higher level that biotin may work with Chasteberry extract to reduce or eliminate the PMS symptoms previously mentioned, as well as weight gain, acne, hair loss and of course, migraines.

Low blood sugar is frequently associated with migraine attacks. The lower the blood sugar level, the more severe the attack can be. Often blood sugar levels drop, not because we haven’t consumed sugar, but because we initially didn’t release enough insulin to lower it or we don’t respond well to the insulin we produce.

This makes the body release even more insulin causing blood sugar levels to drop precipitously. This large fluctuation in both insulin and blood sugar levels can contribute to you developing a migraine.

Biotin at the doses included in MigreLief+M has been shown in numerous studies to help regulate both insulin and blood sugar levels, even in diabetics. (26,27)

Pyridoxine Hydrochloride – Vitamin B-6
Multiple human studies (listed below) in almost 1000 women, have shown that vitamin B-6, at the dose found in MigreLief+M, helps to alleviate PMS symptoms of breast pain, irritability, depression, cravings and bloating.(28-34)

L-THEANINE
Theanine is an amino acid found in green tea that is very calming and can lessen the symptoms of PMS.

A study in Japan showed that taking the dose of theanine found in MigreLief+M increased alpha waves in the brain. This is an effect similar to what occurs when one relaxes in a hot bath or gets a massage, but does not cause drowsiness.

These studies also demonstrate that theanine may reduce mental and physical stress and improve both cognition and mood, all of which are important benefits for women suffering with PMS. (35-37).

15- Gomez-Ramirez M; Higgins, BA; Rycroft, JA; Owen, GN; Mahoney, J; Shpaner, M; Foxe, JJ (2007). “The Deployment of Intersensory Selective Attention: A High-density Electrical Mapping Study of the Effects of Theanine”. Clin Neuropharmacol 30 (1): 25–38.

16- Kimura K, Ozeki M, Juneja L, Ohira H (2007). “L-Theanine reduces psychological and physiological stress responses”. Biol Psychol 74 (1): 39–45.  

17- Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB (2008). “The effects of l-theanine, caffeine and their combination on cognition and mood”. Biol Psychol 77 (2): 113–22.