MigreLief

Magnesium

Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone. These include: 1) inhibition of platelet aggregation; 2) interference with synthesis, release, and action of inflammatory mediators; 3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency, far above what’s found in most multi-vitamins. Several double blind placebo controlled studies have demonstrated that oral magnesium can reduce the frequency and intensity of migraine headaches in both adults and children. (11-16)

Riboflavin

Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin, which is significantly higher than most multi-vitamins or B-complex products. Multiple studies have demonstrated that high dose riboflavin can reduce the frequency and intensity of migraines in both adults and children. (17-20)

Feverfew

Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum Parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus Puracol Feverfew, AKESO HEALTH SCIENCE’S proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide was developed. Puracol Feverfew is just one of the reasons for the superior efficacy of MigreLief, which delivers optimal dosages of parthenolide. Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena is associated with migraines. European studies have shown the benefits of feverfew on long-term cerebrovasular tone in multiple human studies. (1-10)