Topiramate (brand name Topamax) an anti-seizure prescription drug that is also used for migraine prevention, has been found to significantly increase the risk of birth defects when used by pregnant women.
Infants who were exposed to Topamax while in the womb had a 1.4% prevalence of oral clefts (cleft palates) compared to just .38-.55% with other antiepileptic drugs.
Dr. Russell Katz of the FDA states – “Before topirmate is prescribed, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while taking this drug.” “Alternative medications that have a lower risk of birth defect should be considered.”
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More Common and Serious Side Effects of Topamax